Fall 2013 H7N9 Human Genetic Diversity

Sequences discussed in this analysis are variously stored publicly at GenBank and at GISAID. We gratefully acknowledge the authors, originating and submitting laboratories of the sequences from GenBank and from GISAID’s EpiFlu™ Database on which this research is based. A GISAID-generated list is detailed in a linked Excel for completeness in citation.

Publish Date : 2013-12-09
Last Update : 2013-12-09

The GeneWurx Comparative targeting five segments from the Antigens & the Polymerase Complex demonstrates the genetic diversity of the four most recently deposited human eH7N9 sequences covering three cases.  The genetic record shows that at least three distinct constellations have circulated during late summer and fall of 2013.

The active acquisition of segment & sub-segment genetic material from avian reservoirs, circulating human seasonal reservoirs (pH1N1 & sH3N2) and human / zoonotic serotypes is certainly a point of interest. This charted high temporal concentration of variance suggests that the Emergent H7N9 reservoir is in full Host Switching mode and is seeking Gain of Function with Antigenic Novelty.

Human H7N9 Segment Comparative
Guangdong Huizhou 51F 2013_08_10 (GD) Seg Sero Note  HA   H7N9   Novel   NA   H7N9   Base   PB2   H9N2   Assort   PB1   H9N2   Assort   PA   H7N9   Novel	Zhejiang Shaoxing 35M 2013_10_14 (ZC) Seg Sero Note  HA   H7N9   Novel   NA   H7N9   Novel   PB2   H7N9   AvBase   PB1   H7N9   Novel   PA   H7N9   =ZU	Zhejiang Shaoxing 35M 2013_10_14 (ZU) Seg Sero Note  HA   H7N9   Novel   NA   H7N9   Novel   PB2   H7N9   Novel   PB1   H7N9   Novel   PA   H7N9   =ZC	Hong Kong 36F 2013_11_30 (HK) Seg Sero Note  HA   H7N9   ~,!=GD   NA   H7N9   Novel   PB2   H9N2   Assort ~,!=GD   PB1   H9N2   Assort !~GD   PA   H9N2   Assort
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